12th Annual Screen Actors Guild Awards (2006)
- Date of Ceremony: Sunday, January 29, 2006
- For performances seen in: 2005
- Nominations Announcement: Thursday, January 5, 2006
- Location: Shrine Auditorium, Los Angeles, CA
The 12th Annual Screen Actors Guild Awards took place on Sunday, January 29, 2006 and for the first time the ceremony was simultaneously on two networks, TNT and TBS.
SAG’s 42nd Life Achievement Award recipient was Shirley Temple Black.
- Brokeback Mountain: 4
- Empire Falls: 4
- Boston Legal: 4
- Capote: 3
- Grey's Anatomy: 3
- Crash: 3